When playing live, I use two different settings; Stereo + Kick, and Individual Outs. The first setup is mainly for when we are short on time for soundcheck/setup or if we are using an unfamiliar engineer. The second setup is for when we have more time to soundcheck and we have worked with the engineer before.
When using Stereo + Kick, the module is setup thus:
Out 1 - Kit L (minus Kick Drum)
Out 2 - Kit R (minus Kick Drum)
Out 6 - Kick Drum
In this setup, the headphone out is connected to inputs 1 and 2 of my mixer, with a third channel used for the kick drum (coming back from the DI Box). This setup gives any FOH guy some flexibility with regards to Kick Drum level in relation to the rest of the kit.
When using Individual Outs, the module is setup thus:
Out 1 - Toms L
Out 2 - Toms R
Out 3 - Cymbals
Out 4 - Hi Hat
Out 5 - Snare Drum
Out 6 - Kick Drum
In this instance, the headphone output is connected to my onstage Mixer in inputs 1 and 2. This way I can use the internal mixer to suit my monitors and let FOH do their thing.
The reason for the reversed output, is that I can change between the setups quickly (by changing Out 1+2 to the kit mix and then taking out the kick drum in the internal mixer, and vice versa).
On a side note, I'm now using a Roland TD-12 with a VH-11 in conjunction with the 2Box... Will elaborate in a separate post.
Hope this helps!
Ant.